What supplements help with MDMA harm reduction?

Common supplements include: Alpha Lipoic Acid (antioxidant), Magnesium (reduces jaw clenching), Vitamin C (antioxidant), and 5-HTP (taken 24+ hours after, not before or during). Research the RollSafe protocol for detailed guidance.

How is MDMA different from classical psychedelics for microdosing?

Classical psychedelics (psilocybin, LSD) work primarily on serotonin 2A receptors and show no neurotoxicity at any dose. MDMA causes serotonin release and has demonstrated neurotoxicity, especially with frequent use or high doses.

What are the effects of a sub-threshold MDMA dose?

At 10-25mg, effects may include subtle mood lift, slight increase in sociability, and mild stimulation. These effects are much less pronounced than a full dose and may not be noticeable to everyone.

Microdose

MDMA Microdose Calculator | Low-Dose Guide

Calculate MDMA microdoses based on body weight. Includes harm reduction guidelines and timing recommendations.

MDMA Microdose

Calculate MDMA microdoses based on body weight. Includes harm reduction guidelines and timing recommendations.

Body WeightYour body weight for dose calculation

Dose LevelSelect your intended dose range

MDMA is a controlled substance. Unlike classical psychedelics, MDMA has known neurotoxicity risks. Most harm reduction experts do not recommend MDMA microdosing due to potential serotonin system damage with frequent use. This calculator is for educational purposes only.

Important Disclaimer

About This Calculator

MDMA microdosing is more controversial than psilocybin or LSD microdosing due to MDMA's neurotoxicity profile. While some explore sub-threshold doses, most experts recommend limiting MDMA use to infrequent occasions with proper harm reduction practices.

How It Works

Enter your body weight and select a dose level. The calculator provides weight-based recommendations. Note that 'microdosing' MDMA is not well-studied and carries different risks than classical psychedelic microdosing.

Frequently Asked Questions

MDMA microdosing is more controversial than psilocybin or LSD microdosing. MDMA has known neurotoxicity, particularly affecting serotonin neurons. Most harm reduction experts recommend limiting MDMA use to once every 1-3 months, making regular microdosing inadvisable.

Clinical Review

Dr. Igor I. Bussel, MD

Board-Certified Ophthalmologist

Dr. Igor I. Bussel is a board-certified ophthalmologist and fellowship-trained surgeon affiliated with the University of California, Irvine (UCI), the Gavin Herbert Eye Institute, and the UCI School of Medicine.

Last Updated: 2025-01-05

Sources & Guidelines

Medically Reviewed

Evidence-Based

Updated 2025-01-05

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References

Reviewed by: Harm Reduction Team (Educational Content Specialists)

Last updated: 2025-01-05