What is the recommended titration schedule?

Research protocols typically start at 2mg weekly for 4 weeks, then increase to 4mg, 8mg, and potentially 12mg in 4-week intervals to minimize gastrointestinal effects.

How should Retatrutide be stored?

Lyophilized Retatrutide should be stored frozen. Once reconstituted, store refrigerated (2-8°C) and use within 4 weeks.

Peptides+ Chart

Retatrutide Reconstitution & Dosage Calculator

Calculate Retatrutide reconstitution and weekly dosing. Triple agonist (GLP-1/GIP/Glucagon) peptide calculator with titration schedule.

Retatrutide

Calculate Retatrutide reconstitution and weekly dosing. Triple agonist (GLP-1/GIP/Glucagon) peptide calculator with titration schedule.

Vial SizeTotal peptide content in your vial

BAC Water AddedAmount of bacteriostatic water to reconstitute with

Weekly DoseFollow titration schedule - doses higher than phase 3 trials

For research purposes only. Retatrutide is an investigational compound not approved for human use. Always work with qualified professionals.

Visual Syringe Guide

Use this interactive syringe visualization to verify your calculated dose. Enter the volume from your calculation above to see exactly where the plunger should land.

Syringe Configuration

Desired Volume (mL)

Quick Select

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Administration Note

For a 0.50 mL dose, pull the plunger back until the top ring of the black stopper aligns with the corresponding mark.

Volume Match0.50 mL

Important Disclaimer

For research purposes only. Retatrutide is an investigational compound not approved for human use. Always work with qualified professionals.

About This Calculator

Retatrutide is a novel triple agonist peptide targeting GLP-1, GIP, and glucagon receptors simultaneously. This calculator helps researchers determine precise reconstitution ratios and dosing volumes.

How It Works

Enter your vial size, the amount of bacteriostatic water for reconstitution, and select your target weekly dose based on your titration phase. The calculator provides the exact volume needed per injection.

Frequently Asked Questions

Retatrutide is a triple agonist (GLP-1/GIP/Glucagon) while Semaglutide is a single GLP-1 agonist. The additional receptor activity may provide enhanced metabolic effects in research settings.

Clinical Review

Dr. Igor I. Bussel, MD

Board-Certified Ophthalmologist

Dr. Igor I. Bussel is a board-certified ophthalmologist and fellowship-trained surgeon affiliated with the University of California, Irvine (UCI), the Gavin Herbert Eye Institute, and the UCI School of Medicine.

Last Updated: 2026-01-06

Sources & Guidelines

Jastreboff AM, et al. "Triple-Hormone-Receptor Agonist Retatrutide for Obesity." NEJM, 2023.

Medically Reviewed

Evidence-Based

Updated 2026-01-06

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References

Jastreboff AM, et al. "Triple-Hormone-Receptor Agonist Retatrutide for Obesity." NEJM, 2023.

Last updated: 2026-01-06