How often is Semaglutide administered?

Semaglutide is typically administered once weekly, on the same day each week. It can be taken with or without food.

How should reconstituted Semaglutide be stored?

Store reconstituted Semaglutide refrigerated (2-8°C). Use within 4 weeks of reconstitution. Do not freeze after reconstitution.

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Semaglutide Reconstitution & Dosage Calculator

Calculate Semaglutide reconstitution and weekly dosing. Determine precise volumes for titration schedules from 0.25mg to 2.4mg weekly doses.

Semaglutide

Calculate Semaglutide reconstitution and weekly dosing. Determine precise volumes for titration schedules from 0.25mg to 2.4mg weekly doses.

Vial SizeTotal peptide content in your vial

BAC Water AddedAmount of bacteriostatic water to reconstitute with

Weekly DoseFollow titration schedule to minimize side effects

For research purposes only. Semaglutide is a prescription medication. Always work with a licensed healthcare provider.

Visual Syringe Guide

Use this interactive syringe visualization to verify your calculated dose. Enter the volume from your calculation above to see exactly where the plunger should land.

Syringe Configuration

Desired Volume (mL)

Quick Select

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Administration Note

For a 0.50 mL dose, pull the plunger back until the top ring of the black stopper aligns with the corresponding mark.

Volume Match0.50 mL

Important Disclaimer

For research purposes only. Semaglutide is a prescription medication. Always work with a licensed healthcare provider.

About This Calculator

Semaglutide is a GLP-1 receptor agonist used in research related to metabolic function. This calculator helps determine precise reconstitution ratios and dosing volumes following standard titration protocols.

How It Works

Enter your vial size, the amount of bacteriostatic water for reconstitution, and select your target weekly dose based on your titration phase. The calculator provides the exact volume needed per injection.

Frequently Asked Questions

Gradual dose escalation over 16+ weeks helps minimize gastrointestinal side effects like nausea. Starting at 0.25mg and slowly increasing allows the body to adapt.

Clinical Review

Dr. Igor I. Bussel, MD

Board-Certified Ophthalmologist

Dr. Igor I. Bussel is a board-certified ophthalmologist and fellowship-trained surgeon affiliated with the University of California, Irvine (UCI), the Gavin Herbert Eye Institute, and the UCI School of Medicine.

Last Updated: 2026-01-06

Sources & Guidelines

Wilding JPH, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." NEJM, 2021.

Medically Reviewed

Evidence-Based

Updated 2026-01-06

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References

Wilding JPH, et al. "Once-Weekly Semaglutide in Adults with Overweight or Obesity." NEJM, 2021.

Last updated: 2026-01-06