How long should titration take?

Standard titration takes 16-20 weeks, increasing dose every 4 weeks. This gradual approach minimizes gastrointestinal side effects.

What are common side effects?

Gastrointestinal effects (nausea, vomiting, diarrhea) are most common, especially during dose increases. These typically diminish over time.

Peptides+ Chart

Tirzepatide Reconstitution & Dosage Calculator

Calculate Tirzepatide reconstitution and weekly dosing. Dual agonist (GLP-1/GIP) peptide calculator with proper titration schedule from 2.5mg to 15mg.

Tirzepatide

Calculate Tirzepatide reconstitution and weekly dosing. Dual agonist (GLP-1/GIP) peptide calculator with proper titration schedule from 2.5mg to 15mg.

Vial SizeTotal peptide content in your vial

BAC Water AddedAmount of bacteriostatic water to reconstitute with

Weekly DoseFollow titration schedule to minimize side effects

For research purposes only. Tirzepatide is a prescription medication (Mounjaro/Zepbound). Always work with a licensed healthcare provider.

Visual Syringe Guide

Use this interactive syringe visualization to verify your calculated dose. Enter the volume from your calculation above to see exactly where the plunger should land.

Syringe Configuration

Desired Volume (mL)

Quick Select

0.0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

1.0

Administration Note

For a 0.50 mL dose, pull the plunger back until the top ring of the black stopper aligns with the corresponding mark.

Volume Match0.50 mL

Important Disclaimer

For research purposes only. Tirzepatide is a prescription medication (Mounjaro/Zepbound). Always work with a licensed healthcare provider.

About This Calculator

Tirzepatide is a dual GLP-1/GIP receptor agonist. This calculator helps determine precise reconstitution ratios and dosing volumes following standard titration protocols.

How It Works

Enter your vial size, the amount of bacteriostatic water for reconstitution, and select your target weekly dose based on your titration phase. The calculator provides the exact volume needed per injection.

Frequently Asked Questions

Tirzepatide is a dual agonist (GLP-1 + GIP) while Semaglutide is a single GLP-1 agonist. The dual mechanism may provide different metabolic effects.

Clinical Review

Dr. Igor I. Bussel, MD

Board-Certified Ophthalmologist

Dr. Igor I. Bussel is a board-certified ophthalmologist and fellowship-trained surgeon affiliated with the University of California, Irvine (UCI), the Gavin Herbert Eye Institute, and the UCI School of Medicine.

Last Updated: 2026-01-06

Sources & Guidelines

Jastreboff AM, et al. "Tirzepatide Once Weekly for the Treatment of Obesity." NEJM, 2022.

Medically Reviewed

Evidence-Based

Updated 2026-01-06

Related Calculators

Peptide Reconstitution

Calculate the correct amount of bacteriostatic water to add to peptide vials. Get precise mcg per tick mark for insulin syringes.

Peptides+ Chart

mg/kg Calculator

Calculate medication dosage based on body weight using the mg/kg formula. Essential for weight-based dosing in pediatric and adult medicine.

General Dose Math

mg ↔ mL Calculator

Convert between milligrams (mg) and milliliters (mL) using medication concentration. Essential for liquid medication dosing.

General Dose Math

Amoxicillin 400mg/5mL

Calculate the correct mL dose of amoxicillin 400mg/5mL suspension for children based on weight. Includes standard and high-dose options.

Pediatric

References

Jastreboff AM, et al. "Tirzepatide Once Weekly for the Treatment of Obesity." NEJM, 2022.

Last updated: 2026-01-06